-Frank Sign
is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across
the lobule to the rear edge of the auricle. The sign is named after Dr. Sanders
T. Frank.
Dr. Frank was the
first who has noticed it in 1973 and worked on the thesis of a possible
connection between this sign with the development of atherosclerosis and
cardiovascular disease. Based on his observations, over 40 studies are conveyed
which have shown that this sign is a possible indicator of heart disease and
diseases associated with blood vessels.
The study was
conducted on 60 people who were divided into two groups:
-The first group of
patients, group A, which had Frank’s sign.
-Second group of
patients, Group B, without the sign.
The study showed
that 73% of the participants with Frank’s sign had an increased risk of
cerebrovascular disease. In addition, 30% of the patients who didn’t have this
sign had an increased risk of cerebrovascular disease.
The researchers
concluded that the results showed statistically significant correlation between
the Frank’s sign and the potential risk of cerebrovascular disease, stroke and
brain disorders related to damaged blood vessels.
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